5USQ

ALK-5 kinase inhibitor complex

Summary for 5USQ

Entry DOI	10.2210/pdb5usq/pdb
Descriptor	TGF-beta receptor type-1, N-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2H-pyrazolo[4,3-b]pyridin-7-amine (3 entities in total)
Functional Keywords	tgf-beta receptor type i, serine/threonine-protein kinase receptor r4, activin receptor-like kinase 5, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P36897
Total number of polymer chains	1
Total formula weight	34702.31
Authors	Dougan, D.R.,Lawson, J.D. (deposition date: 2017-02-13, release date: 2017-04-12, Last modification date: 2024-03-06)
Primary citation	Sabat, M.,Wang, H.,Scorah, N.,Lawson, J.D.,Atienza, J.,Kamran, R.,Hixon, M.S.,Dougan, D.R. Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors. Bioorg. Med. Chem. Lett., 27:1955-1961, 2017 Cited by PubMed: 28359790 DOI: 10.1016/j.bmcl.2017.03.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation