5UPQ

Acyl-CoA synthetase PtmA2 from Streptomyces platensis in complex with SBNP465 ligand

Summary for 5UPQ

• Entry DOI: 10.2210/pdb5upq/pdb
• Related: 5E7Q 5UPS 5UPT
• Descriptor: Acyl-CoA synthetase PtmA2, 5'-O-[(R)-{[(7beta,8alpha,9beta,10alpha,13alpha,16beta)-7,16-dihydroxy-18-oxokauran-18-yl]oxy}(hydroxy)phosphoryl]adenosine, SULFATE ION, ... (6 entities in total)
• Functional Keywords: acyl-coa synthetase, ptma2, structural genomics, apc109894, midwest center for structural genomics, mcsg, enzyme discovery for natural product biosynthesis, natpro, psi-biology, transferase
• Biological source: Streptomyces platensis subsp. rosaceus
• Total number of polymer chains: 2
• Total formula weight: 117714.23

Authors

Osipiuk, J.,Hatzos-Skintges, C.,Endres, M.,Babnigg, G.,Rudolf, J.D.,Chang, C.Y.,Ma, M.,Shen, B.,Phillips Jr., G.N.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2017-02-03, release date: 2017-02-22, Last modification date: 2023-11-15)

• Primary citation: Wang, N.,Rudolf, J.D.,Dong, L.B.,Osipiuk, J.,Hatzos-Skintges, C.,Endres, M.,Chang, C.Y.,Babnigg, G.,Joachimiak, A.,Phillips, G.N.,Shen, B.; Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.; Nat. Chem. Biol., 14:730-737, 2018; PubMed: 29867143; DOI: 10.1038/s41589-018-0061-0

Experimental method

X-RAY DIFFRACTION (2.42 Å)