5UNP

Structure of CDC2-Like Kinase 2 (CLK2) in Complex with Compound T-025 [N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine]

Summary for 5UNP

• Entry DOI: 10.2210/pdb5unp/pdb
• Descriptor: Dual specificity protein kinase CLK2, N~2~-methyl-N~4~-[(pyrimidin-2-yl)methyl]-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (3 entities in total)
• Functional Keywords: protein kinase, dual specificity protein kinase, inhibitor, transferase, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49760
• Total number of polymer chains: 2
• Total formula weight: 87507.01

Authors

Klein, M.G.,Tjhen, R. (deposition date: 2017-01-31, release date: 2018-05-09, Last modification date: 2024-03-06)

• Primary citation: Iwai, K.,Yaguchi, M.,Klein, M.G.; A novel CLK inhibitor exhibits anti-tumor efficacies via modulating pre-mRNA splicing and targeting a MYC-dependent vulnerability; Embo Mol Med, 2018

Experimental method

X-RAY DIFFRACTION (2.92 Å)