5UNP
Structure of CDC2-Like Kinase 2 (CLK2) in Complex with Compound T-025 [N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine]
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Dual specificity protein kinase CLK2 | polymer | 369 | 43371.1 | 2 | UniProt (P49760) Pfam (PF00069) In PDB | Homo sapiens (Human) | CDC-like kinase 2 |
| 2 | A, B | N~2~-methyl-N~4~-[(pyrimidin-2-yl)methyl]-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | non-polymer | 382.4 | 2 | Chemie (8FY) | |||
| 3 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 496 (UniProt: P49760)
| PDB | External Database | Details |
|---|---|---|
| Gly 128 | - | expression tag |
| Gly 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86742.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 764.8 | |
| All* | Total formula weight | 87507.0 |
