5UNH

Synchrotron structure of human angiotensin II type 2 receptor in complex with compound 2 (N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide)

5UNH の概要

• エントリーDOI: 10.2210/pdb5unh/pdb
• 関連するPDBエントリー: 5UNF 5UNG
• 分子名称: Soluble cytochrome b562,Type-2 angiotensin II receptor, N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide (2 entities in total)
• 機能のキーワード: human angiotensin ii receptor complex, gpcr signaling, gpcr, bril, membrane protein, lcp, synchrotron, blood pressure regulation, compound 2 (cpd 2), signaling protein
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P50052
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94256.44

構造登録者

Zhang, H.,Han, G.W.,Batyuk, A.,Ishchenko, A.,White, K.L.,Patel, N.,Sadybekov, A.,Zamlynny, B.,Rudd, M.T.,Hollenstein, K.,Tolstikova, A.,White, T.A.,Hunter, M.S.,Weierstall, U.,Liu, W.,Babaoglu, K.,Moore, E.L.,Katz, R.D.,Shipman, J.M.,Garcia-Calvo, M.,Sharma, S.,Sheth, P.,Soisson, S.M.,Stevens, R.C.,Katritch, V.,Cherezov, V. (登録日: 2017-01-30, 公開日: 2017-04-05, 最終更新日: 2023-10-04)

• 主引用文献: Zhang, H.,Han, G.W.,Batyuk, A.,Ishchenko, A.,White, K.L.,Patel, N.,Sadybekov, A.,Zamlynny, B.,Rudd, M.T.,Hollenstein, K.,Tolstikova, A.,White, T.A.,Hunter, M.S.,Weierstall, U.,Liu, W.,Babaoglu, K.,Moore, E.L.,Katz, R.D.,Shipman, J.M.,Garcia-Calvo, M.,Sharma, S.,Sheth, P.,Soisson, S.M.,Stevens, R.C.,Katritch, V.,Cherezov, V.; Structural basis for selectivity and diversity in angiotensin II receptors.; Nature, 544:327-332, 2017; PubMed: 28379944; DOI: 10.1038/nature22035

実験手法

X-RAY DIFFRACTION (2.9 Å)