5UNG

XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)

Summary for 5UNG

• Entry DOI: 10.2210/pdb5ung/pdb
• Related: 5UNF 5UNH
• Descriptor: Chimera protein of Type-2 angiotensin II receptor and Soluble cytochrome b562, N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (5 entities in total)
• Functional Keywords: human angiotensin ii receptor complex, gpcr signaling, gpcr, bril, membrane protein, lcp, xfel, blood pressure regulation, orthorhombic crystal, compound 1 (cpd 1), signaling protein
• Biological source: Escherichia coli; More
• Total number of polymer chains: 1
• Total formula weight: 47769.26

Authors

Zhang, H.,Han, G.W.,Batyuk, A.,Ishchenko, A.,White, K.L.,Patel, N.,Sadybekov, A.,Zamlynny, B.,Rudd, M.T.,Hollenstein, K.,Tolstikova, A.,White, T.A.,Hunter, M.S.,Weierstall, U.,Liu, W.,Babaoglu, K.,Moore, E.L.,Katz, R.D.,Shipman, J.M.,Garcia-Calvo, M.,Sharma, S.,Sheth, P.,Soisson, S.M.,Stevens, R.C.,Katritch, V.,Cherezov, V. (deposition date: 2017-01-30, release date: 2017-04-05, Last modification date: 2023-10-04)

• Primary citation: Zhang, H.,Han, G.W.,Batyuk, A.,Ishchenko, A.,White, K.L.,Patel, N.,Sadybekov, A.,Zamlynny, B.,Rudd, M.T.,Hollenstein, K.,Tolstikova, A.,White, T.A.,Hunter, M.S.,Weierstall, U.,Liu, W.,Babaoglu, K.,Moore, E.L.,Katz, R.D.,Shipman, J.M.,Garcia-Calvo, M.,Sharma, S.,Sheth, P.,Soisson, S.M.,Stevens, R.C.,Katritch, V.,Cherezov, V.; Structural basis for selectivity and diversity in angiotensin II receptors.; Nature, 544:327-332, 2017; PubMed: 28379944; DOI: 10.1038/nature22035

Experimental method

X-RAY DIFFRACTION (2.8 Å)