5UM8

Crystal structure of HIV-1 envelope trimer 16055 NFL TD CC (T569G) in complex with Fabs 35022 and PGT124

Summary for 5UM8

• Entry DOI: 10.2210/pdb5um8/pdb
• Descriptor: glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
• Functional Keywords: hiv-1 antibody glycoprotein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 179603.35

Authors

Garces, F.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2017-01-26, release date: 2017-05-24, Last modification date: 2023-10-04)

• Primary citation: Guenaga, J.,Garces, F.,de Val, N.,Stanfield, R.L.,Dubrovskaya, V.,Higgins, B.,Carrette, B.,Ward, A.B.,Wilson, I.A.,Wyatt, R.T.; Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.; Immunity, 46:792-803.e3, 2017; PubMed: 28514686; DOI: 10.1016/j.immuni.2017.04.014

Experimental method

X-RAY DIFFRACTION (3.935 Å)