5UKF
Crystal Structure of the Human Vaccinia-related Kinase 1 Bound to an Oxindole Inhibitor
Summary for 5UKF
Entry DOI | 10.2210/pdb5ukf/pdb |
Descriptor | Serine/threonine-protein kinase VRK1, 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 166712.96 |
Authors | Counago, R.M.,Wells, C.,Zuercher, W.,Willson, T.M.,Bountra, C.,Edwards, A.M.,Arruda, P.,Gileadi, O.,Structural Genomics Consortium (SGC) (deposition date: 2017-01-22, release date: 2017-03-29, Last modification date: 2023-10-04) |
Primary citation | Counago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O. Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7:7501-7501, 2017 Cited by PubMed: 28790404DOI: 10.1038/s41598-017-07755-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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