5UK8
The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR
5UK8 の概要
エントリーDOI | 10.2210/pdb5uk8/pdb |
関連するPDBエントリー | 5UKJ 5UL1 |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine, ... (4 entities in total) |
機能のキーワード | inhibitor, lipid kinase, mutation, atr, transferase-signaling protein-inhibitor complex, transferase/signaling protein/inhibitor |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 160825.14 |
構造登録者 | |
主引用文献 | Lu, Y.,Knapp, M.,Crawford, K.,Warne, R.,Elling, R.,Yan, K.,Doyle, M.,Pardee, G.,Zhang, L.,Ma, S.,Mamo, M.,Ornelas, E.,Pan, Y.,Bussiere, D.,Jansen, J.,Zaror, I.,Lai, A.,Barsanti, P.,Sim, J. Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429:1684-1704, 2017 Cited by PubMed: 28433539DOI: 10.1016/j.jmb.2017.04.006 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.5 Å) |
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