5UJI

Crystal structure of human T2-Tryptophanyl-tRNA synthetase with H130R mutation

Summary for 5UJI

Entry DOI	10.2210/pdb5uji/pdb
Related	5UJJ
Descriptor	Tryptophan--tRNA ligase, cytoplasmic (1 entity in total)
Functional Keywords	rossmann-fold catalytic domain, anti-codon binding domain, h130r mutation, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	89289.81
Authors	Xu, X.,Yang, X.-L. (deposition date: 2017-01-18, release date: 2018-01-17, Last modification date: 2023-10-04)
Primary citation	Xu, X.,Zhou, H.,Zhou, Q.,Hong, F.,Vo, M.N.,Niu, W.,Wang, Z.,Xiong, X.,Nakamura, K.,Wakasugi, K.,Schimmel, P.,Yang, X.L. An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function. RNA Biol, 15:649-658, 2018 Cited by PubMed: 28910573 DOI: 10.1080/15476286.2017.1377868 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation