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5UIW

Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5

Summary for 5UIW
Entry DOI10.2210/pdb5uiw/pdb
DescriptorC-C chemokine receptor type 5,Rubredoxin chimera, C-C motif chemokine 5, ZINC ION, ... (6 entities in total)
Functional Keywordsg-protein coupled receptor, chemokine receptor, hiv entry inhibitor, hiv-1 r5 isolates co-receptor, receptor-ligand complex, signaling protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total formula weight58590.52
Authors
Zheng, Y.,Qin, L.,Han, G.W.,Gustavsson, M.,Kawamura, T.,Stevens, R.C.,Cherezov, V.,Kufareva, I.,Handel, T.M. (deposition date: 2017-01-15, release date: 2017-06-28, Last modification date: 2023-10-04)
Primary citationZheng, Y.,Han, G.W.,Abagyan, R.,Wu, B.,Stevens, R.C.,Cherezov, V.,Kufareva, I.,Handel, T.M.
Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.
Immunity, 46:1005-1017.e5, 2017
Cited by
PubMed: 28636951
DOI: 10.1016/j.immuni.2017.05.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.204 Å)
Structure validation

217705

건을2024-03-27부터공개중

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