5UIW
Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5
Summary for 5UIW
Entry DOI | 10.2210/pdb5uiw/pdb |
Descriptor | C-C chemokine receptor type 5,Rubredoxin chimera, C-C motif chemokine 5, ZINC ION, ... (6 entities in total) |
Functional Keywords | g-protein coupled receptor, chemokine receptor, hiv entry inhibitor, hiv-1 r5 isolates co-receptor, receptor-ligand complex, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 58590.52 |
Authors | Zheng, Y.,Qin, L.,Han, G.W.,Gustavsson, M.,Kawamura, T.,Stevens, R.C.,Cherezov, V.,Kufareva, I.,Handel, T.M. (deposition date: 2017-01-15, release date: 2017-06-28, Last modification date: 2023-10-04) |
Primary citation | Zheng, Y.,Han, G.W.,Abagyan, R.,Wu, B.,Stevens, R.C.,Cherezov, V.,Kufareva, I.,Handel, T.M. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity, 46:1005-1017.e5, 2017 Cited by PubMed: 28636951DOI: 10.1016/j.immuni.2017.05.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.204 Å) |
Structure validation
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