5UHM

Apo-Structure of Mature Growth Differentiation Factor 11

5UHM の概要

• エントリーDOI: 10.2210/pdb5uhm/pdb
• 分子名称: Growth/differentiation factor 11 (2 entities in total)
• 機能のキーワード: tgfb gdf11 apo activin, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : O95390
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24942.62

構造登録者

Goebel, E.,Thompson, T. (登録日: 2017-01-11, 公開日: 2017-03-22, 最終更新日: 2024-11-06)

主引用文献

Walker, R.G.,Czepnik, M.,Goebel, E.J.,McCoy, J.C.,Vujic, A.,Cho, M.,Oh, J.,Aykul, S.,Walton, K.L.,Schang, G.,Bernard, D.J.,Hinck, A.P.,Harrison, C.A.,Martinez-Hackert, E.,Wagers, A.J.,Lee, R.T.,Thompson, T.B.
Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15:19-19, 2017

PubMed Abstract: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are conflicting studies on the function of GDF11 and whether GDF11 has beneficial effects on age-related dysfunction. To address whether GDF8 and GDF11 are functionally identical, we compared their signaling and structural properties.

PubMed: 28257634
DOI: 10.1186/s12915-017-0350-1

実験手法

X-RAY DIFFRACTION (1.9 Å)