5UGM

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Edaglitazone

5UGM の概要

• エントリーDOI: 10.2210/pdb5ugm/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (5R)-5-({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}methyl)-1,3-thiazolidine-2,4-dione, nonanoic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptors, tzds, drug design, therapeutic targets, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64168.75

構造登録者

Shang, J.,Kojetin, D.J. (登録日: 2017-01-09, 公開日: 2018-01-17, 最終更新日: 2024-03-06)

• 主引用文献: Shang, J.,Brust, R.,Mosure, S.A.,Bass, J.,Munoz-Tello, P.,Lin, H.,Hughes, T.S.,Tang, M.,Ge, Q.,Kamekencka, T.M.,Kojetin, D.J.; Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma.; Elife, 7:-, 2018; PubMed: 30575522; DOI: 10.7554/eLife.43320

実験手法

X-RAY DIFFRACTION (2.1 Å)