5UGH

Crystal structure of Mat2a bound to the allosteric inhibitor PF-02929366

5UGH の概要

• エントリーDOI: 10.2210/pdb5ugh/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-2, 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine (3 entities in total)
• 機能のキーワード: mat2a, sam, methionine adenosyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 176862.40

構造登録者

Kaiser, S.E.,Feng, J.,Stewart, A.E. (登録日: 2017-01-08, 公開日: 2017-05-17, 最終更新日: 2023-10-04)

• 主引用文献: Quinlan, C.L.,Kaiser, S.E.,Bolanos, B.,Nowlin, D.,Grantner, R.,Karlicek-Bryant, S.,Feng, J.L.,Jenkinson, S.,Freeman-Cook, K.,Dann, S.G.,Wang, X.,Wells, P.A.,Fantin, V.R.,Stewart, A.E.,Grant, S.K.; Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.; Nat. Chem. Biol., 13:785-792, 2017; PubMed: 28553945; DOI: 10.1038/nchembio.2384

実験手法

X-RAY DIFFRACTION (2.062 Å)