5UFZ
HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate
Summary for 5UFZ
Entry DOI | 10.2210/pdb5ufz/pdb |
Descriptor | Protease, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate (3 entities in total) |
Functional Keywords | hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22237.32 |
Authors | Zachary, N.E.R. (deposition date: 2017-01-06, release date: 2018-01-10, Last modification date: 2024-03-06) |
Primary citation | Mitchell, M.L.,Xu, L.,Zachary, N.E.R.,Desai, M.C. Synthesis of Novel HIV-1 Protease Inhibitors via Diasteroselective Henry Reaction with Nitrocyclopropane TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (1.649 Å) |
Structure validation
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