5UFZ

HIV-1 Protease complexed with Inhibitor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate

Summary for 5UFZ

• Entry DOI: 10.2210/pdb5ufz/pdb
• Descriptor: Protease, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2S)-1-(1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}cyclopropyl)-1-hydroxy-3-phenylpropan-2-yl]carbamate (3 entities in total)
• Functional Keywords: hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22237.32

Authors

Zachary, N.E.R. (deposition date: 2017-01-06, release date: 2018-01-10, Last modification date: 2024-03-06)

• Primary citation: Mitchell, M.L.,Xu, L.,Zachary, N.E.R.,Desai, M.C.; Synthesis of Novel HIV-1 Protease Inhibitors via Diasteroselective Henry Reaction with Nitrocyclopropane; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.649 Å)