Structure of AMPK bound to activator

Summary for 5UFU

Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
Functional Keywordskinase, ampk, activator, allostery, transferase-activator complex, transferase/activator
Biological sourceRattus norvegicus (Rat)
Cellular locationCytoplasm  Q5EG47
Total number of polymer chains3
Total molecular weight120588.06
Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2017-01-05, release date: 2017-05-17)
Primary citation
Cokorinos, E.C.,Delmore, J.,Reyes, A.R.,Albuquerque, B.,Kjbsted, R.,Jrgensen, N.O.,Tran, J.L.,Jatkar, A.,Cialdea, K.,Esquejo, R.M.,Meissen, J.,Calabrese, M.F.,Cordes, J.,Moccia, R.,Tess, D.,Salatto, C.T.,Coskran, T.M.,Opsahl, A.C.,Flynn, D.,Blatnik, M.,Li, W.,Kindt, E.,Foretz, M.,Viollet, B.,Ward, J.,Kurumbail, R.G.,Kalgutkar, A.S.,Wojtaszewski, J.F.P.,Cameron, K.O.,Miller, R.A.
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cell Metab., 25:1147-1159.e10, 2017
PubMed: 28467931 (PDB entries with the same primary citation)
DOI: 10.1016/j.cmet.2017.04.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25860.4%5.1%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report