5UFU

Structure of AMPK bound to activator

Summary for 5UFU

• Entry DOI: 10.2210/pdb5ufu/pdb
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
• Functional Keywords: kinase, ampk, activator, allostery, transferase-activator complex, transferase/activator
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm : Q5EG47
• Total number of polymer chains: 3
• Total formula weight: 120588.06

Authors

Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2017-01-05, release date: 2017-05-17)

• Primary citation: Cokorinos, E.C.,Delmore, J.,Reyes, A.R.,Albuquerque, B.,Kjbsted, R.,Jrgensen, N.O.,Tran, J.L.,Jatkar, A.,Cialdea, K.,Esquejo, R.M.,Meissen, J.,Calabrese, M.F.,Cordes, J.,Moccia, R.,Tess, D.,Salatto, C.T.,Coskran, T.M.,Opsahl, A.C.,Flynn, D.,Blatnik, M.,Li, W.,Kindt, E.,Foretz, M.,Viollet, B.,Ward, J.,Kurumbail, R.G.,Kalgutkar, A.S.,Wojtaszewski, J.F.P.,Cameron, K.O.,Miller, R.A.; Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.; Cell Metab., 25:1147-1159.e10, 2017; PubMed: 28467931; DOI: 10.1016/j.cmet.2017.04.010

Experimental method

X-RAY DIFFRACTION (3.45 Å)