5UFU

Structure of AMPK bound to activator

5UFU の概要

• エントリーDOI: 10.2210/pdb5ufu/pdb
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
• 機能のキーワード: kinase, ampk, activator, allostery, transferase-activator complex, transferase/activator
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasm : Q5EG47
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 120588.06

構造登録者

Calabrese, M.F.,Kurumbail, R.G. (登録日: 2017-01-05, 公開日: 2017-05-17)

• 主引用文献: Cokorinos, E.C.,Delmore, J.,Reyes, A.R.,Albuquerque, B.,Kjbsted, R.,Jrgensen, N.O.,Tran, J.L.,Jatkar, A.,Cialdea, K.,Esquejo, R.M.,Meissen, J.,Calabrese, M.F.,Cordes, J.,Moccia, R.,Tess, D.,Salatto, C.T.,Coskran, T.M.,Opsahl, A.C.,Flynn, D.,Blatnik, M.,Li, W.,Kindt, E.,Foretz, M.,Viollet, B.,Ward, J.,Kurumbail, R.G.,Kalgutkar, A.S.,Wojtaszewski, J.F.P.,Cameron, K.O.,Miller, R.A.; Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.; Cell Metab., 25:1147-1159.e10, 2017; PubMed: 28467931; DOI: 10.1016/j.cmet.2017.04.010

実験手法

X-RAY DIFFRACTION (3.45 Å)