5UEW

BRD2 Bromodomain2 with A-1360579

5UEW の概要

• エントリーDOI: 10.2210/pdb5uew/pdb
• 関連するPDBエントリー: 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEX 5UEY 5UEZ 5UF0
• 分子名称: Bromodomain-containing protein 2, N-[3-(4-methoxy-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-phenoxyphenyl]methanesulfonamide (3 entities in total)
• 機能のキーワード: signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P25440
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26850.77

構造登録者

Park, C.H. (登録日: 2017-01-03, 公開日: 2017-05-10, 最終更新日: 2024-03-06)

• 主引用文献: Wang, L.,Pratt, J.K.,Soltwedel, T.,Sheppard, G.S.,Fidanze, S.D.,Liu, D.,Hasvold, L.A.,Mantei, R.A.,Holms, J.H.,McClellan, W.J.,Wendt, M.D.,Wada, C.,Frey, R.,Hansen, T.M.,Hubbard, R.,Park, C.H.,Li, L.,Magoc, T.J.,Albert, D.H.,Lin, X.,Warder, S.E.,Kovar, P.,Huang, X.,Wilcox, D.,Wang, R.,Rajaraman, G.,Petros, A.M.,Hutchins, C.W.,Panchal, S.C.,Sun, C.,Elmore, S.W.,Shen, Y.,Kati, W.M.,McDaniel, K.F.; Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.; J. Med. Chem., 60:3828-3850, 2017; PubMed: 28368119; DOI: 10.1021/acs.jmedchem.7b00017

実験手法

X-RAY DIFFRACTION (1.83 Å)