5UAJ

Escherichia coli RNA polymerase RpoB S531L mutant

5UAJ の概要

• エントリーDOI: 10.2210/pdb5uaj/pdb
• 関連するPDBエントリー: 5UAC 5UAG 5UAH 5UAL 5UAQ
• 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (7 entities in total)
• 機能のキーワード: inhibitor, antibiotic, tuberculosis, rifampin, rifamycin, rna polymerase, rpob s531l, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli (strain K12); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 920176.01

構造登録者

Molodtsov, V.,Scharf, N.T.,Stefan, M.A.,Garcia, G.A.,Murakami, K.S. (登録日: 2016-12-19, 公開日: 2017-01-11, 最終更新日: 2023-10-04)

• 主引用文献: Molodtsov, V.,Scharf, N.T.,Stefan, M.A.,Garcia, G.A.,Murakami, K.S.; Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.; Mol. Microbiol., 103:1034-1045, 2017; PubMed: 28009073; DOI: 10.1111/mmi.13606

実験手法

X-RAY DIFFRACTION (3.915 Å)