5UAD
MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody
Summary for 5UAD
Entry DOI | 10.2210/pdb5uad/pdb |
Related | 5UAB 5UAF |
Descriptor | Hepatocyte growth factor receptor, N-(6-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-benzotriazol-1-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | met, tyrosine kinase, inhibitor, antitumor, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 39027.39 |
Authors | Hoffman, I.D.,Lawson, J.D. (deposition date: 2016-12-19, release date: 2017-05-31, Last modification date: 2024-03-06) |
Primary citation | Farrell, P.J.,Matuszkiewicz, J.,Balakrishna, D.,Pandya, S.,Hixon, M.S.,Kamran, R.,Chu, S.,Lawson, J.D.,Okada, K.,Hori, A.,Mizutani, A.,Iwata, H.,de Jong, R.,Hibner, B.,Vincent, P. MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody. Mol. Cancer Ther., 16:1269-1278, 2017 Cited by PubMed: 28341789DOI: 10.1158/1535-7163.MCT-16-0771 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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