5U8L

Crystal structure of EGFR kinase domain in complex with a sulfonyl fluoride probe XO44

Summary for 5U8L

Entry DOI	10.2210/pdb5u8l/pdb
Descriptor	Epidermal growth factor receptor, 4-[(4-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride, SULFATE ION, ... (5 entities in total)
Functional Keywords	kinase covalent probe covalent inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	38307.21
Authors	Gajiwala, K.S.,Ferre, R. (deposition date: 2016-12-14, release date: 2017-01-25, Last modification date: 2017-02-01)
Primary citation	Zhao, Q.,Ouyang, X.,Wan, X.,Gajiwala, K.S.,Kath, J.C.,Jones, L.H.,Burlingame, A.L.,Taunton, J. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. J. Am. Chem. Soc., 139:680-685, 2017 Cited by PubMed: 28051857 DOI: 10.1021/jacs.6b08536 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation