5U89
Crystal structure of a cross-module fragment from the dimodular NRPS DhbF
Summary for 5U89
Entry DOI | 10.2210/pdb5u89/pdb |
Descriptor | Amino acid adenylation domain protein, MbtH domain protein, 5'-({[(2R)-3-amino-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}propyl]sulfonyl}amino)-5'-deoxyadenosine (3 entities in total) |
Functional Keywords | nonribosomal peptide synthetase, mbth-like protein, mechanism-based inhibitor, megaenzyme, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Geobacillus sp. More |
Total number of polymer chains | 2 |
Total formula weight | 131335.11 |
Authors | Tarry, M.J.,Schmeing, T.M. (deposition date: 2016-12-14, release date: 2017-05-10, Last modification date: 2020-01-08) |
Primary citation | Tarry, M.J.,Haque, A.S.,Bui, K.H.,Schmeing, T.M. X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture. Structure, 25:783-793.e4, 2017 Cited by PubMed: 28434915DOI: 10.1016/j.str.2017.03.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.075 Å) |
Structure validation
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