5U6X

COX-1:P6 COMPLEX STRUCTURE

5U6X の概要

• エントリーDOI: 10.2210/pdb5u6x/pdb
• 関連するPDBエントリー: 3N8Z
• 分子名称: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, p6, oxidoreductase
• 由来する生物種: Ovis aries (Sheep)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 144027.05

構造登録者

Cingolani, G.,Panella, A.,Perrone, M.G.,Vitale, P.,Smith, W.L.,Scilimati, A. (登録日: 2016-12-09, 公開日: 2017-08-09, 最終更新日: 2023-10-04)

• 主引用文献: Cingolani, G.,Panella, A.,Perrone, M.G.,Vitale, P.,Di Mauro, G.,Fortuna, C.G.,Armen, R.S.,Ferorelli, S.,Smith, W.L.,Scilimati, A.; Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).; Eur J Med Chem, 138:661-668, 2017; PubMed: 28710965; DOI: 10.1016/j.ejmech.2017.06.045

実験手法

X-RAY DIFFRACTION (2.93 Å)