5U6X
COX-1:P6 COMPLEX STRUCTURE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0020037 | molecular_function | heme binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ILE74-LEU82 | |
| A | PRO86-LEU92 | |
| A | ARG97-ALA105 | |
| A | ILE108-ASN122 | |
| B | ILE74-LEU82 | |
| B | PRO86-LEU92 | |
| B | ARG97-ALA105 | |
| B | ILE108-ASN122 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | HIS207 | |
| B | HIS207 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: For cyclooxygenase activity => ECO:0000269|PubMed:2122967 |
| Chain | Residue | Details |
| A | TYR385 | |
| B | TYR385 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | HIS388 | |
| B | HIS388 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Not glycosylated => ECO:0000269|PubMed:8349699 |
| Chain | Residue | Details |
| A | ASN104 | |
| B | ASN104 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Aspirin-acetylated serine |
| Chain | Residue | Details |
| A | SER530 | |
| B | SER530 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699 |
| Chain | Residue | Details |
| A | ASN68 | |
| A | ASN144 | |
| A | ASN410 | |
| B | ASN68 | |
| B | ASN144 | |
| B | ASN410 |
