5U4E
Wild-type Transthyretin in complex with 3-[(1E)-2-(2-Chloro-4-boronic acid)ethenyl]benzoic Acid
Summary for 5U4E
| Entry DOI | 10.2210/pdb5u4e/pdb |
| Related | 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4F 5U4G |
| Descriptor | Transthyretin, 3-[(E)-2-(4-borono-2-chlorophenyl)ethenyl]benzoic acid (3 entities in total) |
| Functional Keywords | boronic acids, medicinal chemistry, stilbene, covalent ligand, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28422.15 |
| Authors | Windsor, I.W.,Smith, T.P.,Raines, R.T.,Forest, K.T. (deposition date: 2016-12-03, release date: 2017-09-27, Last modification date: 2023-10-04) |
| Primary citation | Smith, T.P.,Windsor, I.W.,Forest, K.T.,Raines, R.T. Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. J. Med. Chem., 60:7820-7834, 2017 Cited by PubMed: 28920684DOI: 10.1021/acs.jmedchem.7b00952 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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