5U3F
Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative
Summary for 5U3F
| Entry DOI | 10.2210/pdb5u3f/pdb |
| Descriptor | Branched-chain-amino-acid aminotransferase, (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate (3 entities in total) |
| Functional Keywords | branched-chain amino acid transaminase, amino acid biosynthesis, pyridoxal phosphate, inhibitor, d-cycloserine, transferase |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 2 |
| Total formula weight | 80076.26 |
| Authors | Favrot, L.,Amorim Franco, T.M.,Blanchard, J.S. (deposition date: 2016-12-02, release date: 2017-03-22, Last modification date: 2023-10-04) |
| Primary citation | Amorim Franco, T.M.,Favrot, L.,Vergnolle, O.,Blanchard, J.S. Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d- and l-Cycloserine. ACS Chem. Biol., 12:1235-1244, 2017 Cited by PubMed: 28272868DOI: 10.1021/acschembio.7b00142 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.695 Å) |
Structure validation
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