5U3F

Structure of Mycobacterium tuberculosis IlvE, a branched-chain amino acid transaminase, in complex with D-cycloserine derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004084	molecular_function	branched-chain-amino-acid transaminase activity
A	0005515	molecular_function	protein binding
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009098	biological_process	L-leucine biosynthetic process
A	0009099	biological_process	L-valine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0052654	molecular_function	L-leucine-2-oxoglutarate transaminase activity
A	0052655	molecular_function	L-valine-2-oxoglutarate transaminase activity
A	0052656	molecular_function	L-isoleucine-2-oxoglutarate transaminase activity
A	0071267	biological_process	L-methionine salvage
B	0003824	molecular_function	catalytic activity
B	0004084	molecular_function	branched-chain-amino-acid transaminase activity
B	0005515	molecular_function	protein binding
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009098	biological_process	L-leucine biosynthetic process
B	0009099	biological_process	L-valine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
B	0030170	molecular_function	pyridoxal phosphate binding
B	0052654	molecular_function	L-leucine-2-oxoglutarate transaminase activity
B	0052655	molecular_function	L-valine-2-oxoglutarate transaminase activity
B	0052656	molecular_function	L-isoleucine-2-oxoglutarate transaminase activity
B	0071267	biological_process	L-methionine salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue 7TS A 400

Chain	Residue
A	GLY79
A	MET244
A	ASN245
A	LEU268
A	GLY270
A	ILE271
A	THR272
A	GLY313
A	THR314
A	HOH537
A	HOH577
A	ARG101
A	HOH649
A	HOH685
A	TYR144
A	ARG194
A	LYS204
A	TYR209
A	GLU240
A	GLY242
A	GLY243

---

site_id	AC2
Number of Residues	21
Details	binding site for residue 7TS B 400

Chain	Residue
B	GLY79
B	ARG101
B	TYR144
B	ARG194
B	LYS204
B	TYR209
B	GLU240
B	GLY242
B	GLY243
B	MET244
B	ASN245
B	LEU268
B	GLY270
B	ILE271
B	THR272
B	GLY313
B	THR314
B	HOH534
B	HOH556
B	HOH562
B	HOH644

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Functional Information from PROSITE/UniProt

site_id	PS00770
Number of Residues	34
Details	AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EmGgmNIFfvlgsggsar..LvTpelsgsl.LpGItR

Chain	Residue	Details
A	GLU240-ARG273

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	ARG101
A	TYR209
A	ILE271
A	THR314
B	ARG101
B	TYR209
B	ILE271
B	THR314

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-(pyridoxal phosphate)lysine

Chain	Residue	Details
A	LYS204
B	LYS204

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