5U06
Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic
Summary for 5U06
Entry DOI | 10.2210/pdb5u06/pdb |
Related | 5TYI 5U1Q |
Descriptor | Growth factor receptor-bound protein 7, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | grb7, sh2 domain, inhibitor, signalling, signaling protein-peptide inhibitor complex, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 59618.91 |
Authors | Watson, G.M.,Wilce, J.A. (deposition date: 2016-11-22, release date: 2017-11-15, Last modification date: 2020-01-08) |
Primary citation | Watson, G.M.,Kulkarni, K.,Sang, J.,Ma, X.,Gunzburg, M.J.,Perlmutter, P.,Wilce, M.C.J.,Wilce, J.A. Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J. Med. Chem., 60:9349-9359, 2017 Cited by PubMed: 29083893DOI: 10.1021/acs.jmedchem.7b01320 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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