5U06
Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Growth factor receptor-bound protein 7 | polymer | 120 | 13690.7 | 4 | UniProt (Q14451) Pfam (PF00017) In PDB | Homo sapiens (Human) | B47,Epidermal growth factor receptor GRB-7,GRB7 adapter protein |
| 2 | L, M, N, P | bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST | polymer | 9 | 1204.2 | 4 | synthetic construct | ||
| 3 | B | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 415 - 532 (UniProt: Q14451)
| PDB | External Database | Details |
|---|---|---|
| Gly 413 | - | expression tag |
| Ser 414 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 59579.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 39.1 | |
| All* | Total formula weight | 59618.9 |
