5U06

Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic

5U06 の概要

• エントリーDOI: 10.2210/pdb5u06/pdb
• 関連するPDBエントリー: 5TYI 5U1Q
• 分子名称: Growth factor receptor-bound protein 7, bicyclic peptide inhibitor: LYS-PHE-GLU-GLY-CMF-ASP-ASN-GLU-CST, POTASSIUM ION, ... (4 entities in total)
• 機能のキーワード: grb7, sh2 domain, inhibitor, signalling, signaling protein-peptide inhibitor complex, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 59618.91

構造登録者

Watson, G.M.,Wilce, J.A. (登録日: 2016-11-22, 公開日: 2017-11-15, 最終更新日: 2020-01-08)

• 主引用文献: Watson, G.M.,Kulkarni, K.,Sang, J.,Ma, X.,Gunzburg, M.J.,Perlmutter, P.,Wilce, M.C.J.,Wilce, J.A.; Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.; J. Med. Chem., 60:9349-9359, 2017; PubMed: 29083893; DOI: 10.1021/acs.jmedchem.7b01320

実験手法

X-RAY DIFFRACTION (2.1 Å)