5TZ1
Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1)
Summary for 5TZ1
Entry DOI | 10.2210/pdb5tz1/pdb |
Related | 5FSA |
Descriptor | Sterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, ... (4 entities in total) |
Functional Keywords | cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Candida albicans (Yeast) |
Total number of polymer chains | 2 |
Total formula weight | 115158.14 |
Authors | Hargrove, T.,Wawrzak, Z.,Lepesheva, G. (deposition date: 2016-11-21, release date: 2017-03-15, Last modification date: 2023-10-04) |
Primary citation | Hargrove, T.Y.,Friggeri, L.,Wawrzak, Z.,Qi, A.,Hoekstra, W.J.,Schotzinger, R.J.,York, J.D.,Guengerich, F.P.,Lepesheva, G.I. Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. J. Biol. Chem., 292:6728-6743, 2017 Cited by PubMed: 28258218DOI: 10.1074/jbc.M117.778308 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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