5TYH

PglD from Campylobacter jejuni NCTC 11168 in complex with 5-(2-furanyl)-1H-pyrazole-3-carboxylic acid

Summary for 5TYH

Entry DOI	10.2210/pdb5tyh/pdb
Descriptor	UDP-N-acetylbacillosamine N-acetyltransferase, 3-(furan-2-yl)-1H-pyrazole-5-carboxylic acid (3 entities in total)
Functional Keywords	acetyltransferase bacterial n-glycan biosynthesis inhibitor fragment-based discovery, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Total number of polymer chains	1
Total formula weight	21746.25
Authors	Morrison, J.P.,Imperiali, B. (deposition date: 2016-11-20, release date: 2017-04-12, Last modification date: 2023-10-04)
Primary citation	De Schutter, J.W.,Morrison, J.P.,Morrison, M.J.,Ciulli, A.,Imperiali, B. Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni. J. Med. Chem., 60:2099-2118, 2017 Cited by PubMed: 28182413 DOI: 10.1021/acs.jmedchem.6b01869 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation