5TXP
STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP
Summary for 5TXP
Entry DOI | 10.2210/pdb5txp/pdb |
Related | 5TXL 5TXM 5TXN 5TXO |
Related PRD ID | PRD_900003 |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P61 SUBUNIT, DNA (5'-D(*TP*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... (10 entities in total) |
Functional Keywords | rt, dna, crosslink, n site complex, pyrophosphorolysis, p51, p66, transferase, drug resistance, mutation, transferase-dna complex. dna polymerase, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 8 |
Total formula weight | 260001.87 |
Authors | Das, K.,Martinez, S.M.,Arnold, E. (deposition date: 2016-11-17, release date: 2017-04-05, Last modification date: 2023-10-04) |
Primary citation | Das, K.,Martinez, S.E.,Arnold, E. Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61:-, 2017 Cited by PubMed: 28396546DOI: 10.1128/AAC.00224-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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