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5TXO

STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP

Summary for 5TXO
Entry DOI10.2210/pdb5txo/pdb
Related5TXL 5TXM 5TXN 5TXP
Related PRD IDPRD_900003
DescriptorHIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (5'-D(*TP*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... (10 entities in total)
Functional Keywordsrt, dna, crosslink, n site complex, pyrophosphorolysis, p51, p66, transferase, drug resistance, mutation, transferase-dna complex. dna polymerase, transferase-dna complex, transferase/dna
Biological sourceHuman immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
More
Total number of polymer chains8
Total formula weight260005.80
Authors
Das, K.,Martinez, S.M.,Arnold, E. (deposition date: 2016-11-17, release date: 2017-04-05, Last modification date: 2023-10-04)
Primary citationDas, K.,Martinez, S.E.,Arnold, E.
Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.
Antimicrob. Agents Chemother., 61:-, 2017
Cited by
PubMed: 28396546
DOI: 10.1128/AAC.00224-17
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.546 Å)
Structure validation

217705

건을2024-03-27부터공개중

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