5TX5
Rip1 Kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772
Summary for 5TX5
Entry DOI | 10.2210/pdb5tx5/pdb |
Descriptor | Receptor-interacting serine/threonine-protein kinase 1, 3-benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide (3 entities in total) |
Functional Keywords | kinase domain inhibitor necrosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q13546 |
Total number of polymer chains | 2 |
Total formula weight | 69948.58 |
Authors | Campobasso, N.,Ward, P.,Thrope, J. (deposition date: 2016-11-15, release date: 2017-07-05, Last modification date: 2024-03-06) |
Primary citation | Harris, P.A.,Berger, S.B.,Jeong, J.U.,Nagilla, R.,Bandyopadhyay, D.,Campobasso, N.,Capriotti, C.A.,Cox, J.A.,Dare, L.,Dong, X.,Eidam, P.M.,Finger, J.N.,Hoffman, S.J.,Kang, J.,Kasparcova, V.,King, B.W.,Lehr, R.,Lan, Y.,Leister, L.K.,Lich, J.D.,MacDonald, T.T.,Miller, N.A.,Ouellette, M.T.,Pao, C.S.,Rahman, A.,Reilly, M.A.,Rendina, A.R.,Rivera, E.J.,Schaeffer, M.C.,Sehon, C.A.,Singhaus, R.R.,Sun, H.H.,Swift, B.A.,Totoritis, R.D.,Vossenkamper, A.,Ward, P.,Wisnoski, D.D.,Zhang, D.,Marquis, R.W.,Gough, P.J.,Bertin, J. Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J. Med. Chem., 60:1247-1261, 2017 Cited by PubMed: 28151659DOI: 10.1021/acs.jmedchem.6b01751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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