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5TWM

CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide

5TWM の概要
エントリーDOI10.2210/pdb5twm/pdb
関連するPDBエントリー5TWN
分子名称NS5B RNA-dependent RNA POLYMERASE, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, SULFATE ION, ... (6 entities in total)
機能のキーワードrdrp structure (fingers, palm, thumb domains), acetylation, apoptosis, atp-binding, capsid protein, cell membrane, cytoplasm, disulfide bond, endoplasmic reticulum, envelope protein, fusion protein, glycoprotein, helicase, host-virus interaction, hydrolase, interferon antiviral system evasion, lipid droplet, lipoprotein, membrane, metal-binding, mitochondrion, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, nucleus, oncogene, palmitate, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, sh3-binding, thiol protease, transcription, transcription regulation, transferase, transmembrane, ubl conjugation, viral nucleoprotein, virion, zinc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
タンパク質・核酸の鎖数1
化学式量合計65591.15
構造登録者
Sheriff, S. (登録日: 2016-11-14, 公開日: 2017-03-15, 最終更新日: 2023-10-04)
主引用文献Eastman, K.J.,Parcella, K.,Yeung, K.S.,Grant-Young, K.A.,Zhu, J.,Wang, T.,Zhang, Z.,Yin, Z.,Beno, B.R.,Sheriff, S.,Kish, K.,Tredup, J.,Jardel, A.G.,Halan, V.,Ghosh, K.,Parker, D.,Mosure, K.,Fang, H.,Wang, Y.K.,Lemm, J.,Zhuo, X.,Hanumegowda, U.,Rigat, K.,Donoso, M.,Tuttle, M.,Zvyaga, T.,Haarhoff, Z.,Meanwell, N.A.,Soars, M.G.,Roberts, S.B.,Kadow, J.F.
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8:796-806, 2017
Cited by
PubMed: 30108798
DOI: 10.1039/c6md00636a
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.97 Å)
構造検証レポート
Validation report summary of 5twm
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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