5TWE
CTX-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime
Summary for 5TWE
Entry DOI | 10.2210/pdb5twe/pdb |
Related | 5TW6 5TWD |
Descriptor | Beta-lactamase, ACYLATED CEFTAZIDIME (3 entities in total) |
Functional Keywords | ctx-m beta-lactamase ceftazidime, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 28429.97 |
Authors | Patel, M.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2016-11-12, release date: 2017-06-28, Last modification date: 2023-10-04) |
Primary citation | Patel, M.P.,Hu, L.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry, 56:3443-3453, 2017 Cited by PubMed: 28613873DOI: 10.1021/acs.biochem.7b00176 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report