5TWD

CTX-M-14 P167S apoenzyme

Summary for 5TWD

• Entry DOI: 10.2210/pdb5twd/pdb
• Related: 5TW6 5TWE
• Descriptor: Beta-lactamase (2 entities in total)
• Functional Keywords: ctx-m beta-lactamase apoenzyme, hydrolase/antibiotic, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 27990.51

Authors

Patel, M.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2016-11-12, release date: 2017-06-28, Last modification date: 2023-10-04)

• Primary citation: Patel, M.P.,Hu, L.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T.; The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.; Biochemistry, 56:3443-3453, 2017; PubMed: 28613873; DOI: 10.1021/acs.biochem.7b00176

Experimental method

X-RAY DIFFRACTION (1.7 Å)