5TVR
JMJD2A in complex with Ni(II) and alpha-Ketoglutarate
Summary for 5TVR
Entry DOI | 10.2210/pdb5tvr/pdb |
Related | 5TVS |
Descriptor | Lysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total) |
Functional Keywords | oxidoreductase demethylase monooxygenase epigenetics, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 84075.49 |
Authors | Cascella, B.,Lee, S.G.,Jez, J.M. (deposition date: 2016-11-09, release date: 2017-02-01, Last modification date: 2024-10-30) |
Primary citation | Cascella, B.,Lee, S.G.,Singh, S.,Jez, J.M.,Mirica, L.M. The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A. Chem. Commun. (Camb.), 53:2174-2177, 2017 Cited by PubMed Abstract: JIB-04, a specific inhibitor of the O-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O in KDM4A/JMJD2A through a continuous O-consumption assay, X-ray crystal structure data, and molecular docking. PubMed: 28144654DOI: 10.1039/c6cc09882g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.093 Å) |
Structure validation
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