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5TVR

JMJD2A in complex with Ni(II) and alpha-Ketoglutarate

Summary for 5TVR
Entry DOI10.2210/pdb5tvr/pdb
Related5TVS
DescriptorLysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total)
Functional Keywordsoxidoreductase demethylase monooxygenase epigenetics, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight84075.49
Authors
Cascella, B.,Lee, S.G.,Jez, J.M. (deposition date: 2016-11-09, release date: 2017-02-01, Last modification date: 2024-10-30)
Primary citationCascella, B.,Lee, S.G.,Singh, S.,Jez, J.M.,Mirica, L.M.
The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53:2174-2177, 2017
Cited by
PubMed Abstract: JIB-04, a specific inhibitor of the O-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O in KDM4A/JMJD2A through a continuous O-consumption assay, X-ray crystal structure data, and molecular docking.
PubMed: 28144654
DOI: 10.1039/c6cc09882g
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.093 Å)
Structure validation

226707

数据于2024-10-30公开中

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