5TV3
Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with (E)-5-(((4-(tert-butyl)phenyl)sulfonyl)imino)-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
Summary for 5TV3
Entry DOI | 10.2210/pdb5tv3/pdb |
Related | 5TT3 5TT8 5TUO |
Descriptor | Alpha-carbonic anhydrase, ZINC ION, (5Z)-5-{[(4-tert-butylphenyl)sulfonyl]imino}-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide, ... (5 entities in total) |
Functional Keywords | alpha-carbonic anhydrase, helicobacter pylori, lyase, zinc-metalloenzyme, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Helicobacter pylori (strain ATCC 700392 / 26695) |
Total number of polymer chains | 8 |
Total formula weight | 219823.05 |
Authors | Modak, J.K.,Roujeinikova, A. (deposition date: 2016-11-07, release date: 2017-09-20, Last modification date: 2023-10-04) |
Primary citation | Modak, J.K.,Liu, Y.C.,Supuran, C.T.,Roujeinikova, A. Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase. J. Med. Chem., 59:11098-11109, 2016 Cited by PubMed: 28002963DOI: 10.1021/acs.jmedchem.6b01333 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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