5TUS

Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule

5TUS の概要

• エントリーDOI: 10.2210/pdb5tus/pdb
• 分子名称: Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: ribonucleotide reductase, small molecule inhibitor, active site inhibitor, competitive inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 181677.31

構造登録者

Mohammed, F.A.,Alam, I.,Dealwis, C.G. (登録日: 2016-11-07, 公開日: 2017-08-02, 最終更新日: 2020-01-01)

• 主引用文献: Ahmad, M.F.,Alam, I.,Huff, S.E.,Pink, J.,Flanagan, S.A.,Shewach, D.,Misko, T.A.,Oleinick, N.L.,Harte, W.E.,Viswanathan, R.,Harris, M.E.,Dealwis, C.G.; Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule.; Proc. Natl. Acad. Sci. U.S.A., 114:8241-8246, 2017; PubMed: 28716944; DOI: 10.1073/pnas.1620220114

実験手法

X-RAY DIFFRACTION (2.66 Å)