5TUQ
Crystal Structure of a 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione Inhibitor in Complex with HIV Reverse Transcriptase
Summary for 5TUQ
Entry DOI | 10.2210/pdb5tuq/pdb |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, 1-[(benzyloxy)methyl]-6-(cyclohexylmethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hiv-1, reverse transcriptase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114612.77 |
Authors | Kirby, K.A.,Sarafianos, S.G. (deposition date: 2016-11-07, release date: 2017-06-28, Last modification date: 2023-10-04) |
Primary citation | Tang, J.,Kirby, K.A.,Huber, A.D.,Casey, M.C.,Ji, J.,Wilson, D.J.,Sarafianos, S.G.,Wang, Z. 6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase. Eur J Med Chem, 128:168-179, 2017 Cited by PubMed: 28182989DOI: 10.1016/j.ejmech.2017.01.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.705 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)