5TTZ
Crystal structure of Grp94 bound to isoform-selective inhibitor methyl 2-(2-(1-(4-bromobenzyl)-1H-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate
5TTZ の概要
エントリーDOI | 10.2210/pdb5ttz/pdb |
分子名称 | Endoplasmin, methyl 2-(2-{1-[(4-bromophenyl)methyl]-1H-imidazol-2-yl}ethyl)-3-chloro-4,6-dihydroxybenzoate, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
機能のキーワード | bnim scaffold, atp binding site, chaperone - inhibitor complex, chaperone / inhibitor |
由来する生物種 | Canis lupus familiaris (Dog) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 54111.64 |
構造登録者 | |
主引用文献 | Stothert, A.R.,Suntharalingam, A.,Tang, X.,Crowley, V.M.,Mishra, S.J.,Webster, J.M.,Nordhues, B.A.,Huard, D.J.E.,Passaglia, C.L.,Lieberman, R.L.,Blagg, B.S.J.,Blair, L.J.,Koren, J.,Dickey, C.A. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Sci Rep, 7:17951-17951, 2017 Cited by PubMed: 29263415DOI: 10.1038/s41598-017-18344-4 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.707 Å) |
構造検証レポート
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