5TTW
Crystal Structure of EED in Complex with UNC4859
Summary for 5TTW
Entry DOI | 10.2210/pdb5ttw/pdb |
Related | 3K26 |
Descriptor | Polycomb protein EED, UNC4859, SULFATE ION, ... (5 entities in total) |
Functional Keywords | wd40, eed peptide inhibitor, transcription regulator-inhibitor complex, transcription regulator/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: O75530 |
Total number of polymer chains | 4 |
Total formula weight | 86170.25 |
Authors | The, J.,Barnash, K.D.,Brown, P.J.,Edwards, A.M.,Bountra, C.,Frye, S.V.,James, L.I.,Arrowsmith, C.H. (deposition date: 2016-11-04, release date: 2017-01-11, Last modification date: 2023-10-04) |
Primary citation | Barnash, K.D.,The, J.,Norris-Drouin, J.L.,Cholensky, S.H.,Worley, B.M.,Li, F.,Stuckey, J.I.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Frye, S.V.,James, L.I. Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. ACS Comb Sci, 19:161-172, 2017 Cited by PubMed: 28165227DOI: 10.1021/acscombsci.6b00174 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
Download full validation report