5TTO
X-ray crystal structure of PPARgamma in complex with SR1643
Summary for 5TTO
Entry DOI | 10.2210/pdb5tto/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 4-bromo-N-{3,5-dichloro-4-[(quinolin-3-yl)oxy]phenyl}-2,5-difluorobenzene-1-sulfonamide (3 entities in total) |
Functional Keywords | nuclear receptor, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 63536.86 |
Authors | Bruning, J.B.,Frkic, R.L.,Griffin, P.,Kamenecka, T.,Abell, A. (deposition date: 2016-11-04, release date: 2017-05-24, Last modification date: 2023-10-04) |
Primary citation | Frkic, R.L.,He, Y.,Rodriguez, B.B.,Chang, M.R.,Kuruvilla, D.,Ciesla, A.,Abell, A.D.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B. Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR gamma-Targeted Antidiabetics. J. Med. Chem., 60:4584-4593, 2017 Cited by PubMed: 28485590DOI: 10.1021/acs.jmedchem.6b01727 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.246 Å) |
Structure validation
Download full validation report