5TQU

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor

Summary for 5TQU

Entry DOI	10.2210/pdb5tqu/pdb
Descriptor	Methionyl-tRNA synthetase, putative, METHIONINE, 2-[2-[[3-(1~{H}-benzimidazol-2-ylamino)propylamino]methyl]-4,6-bis(chloranyl)indol-1-yl]ethanol, ... (6 entities in total)
Functional Keywords	synthetase, ligase, methionine, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Trypanosoma brucei brucei
Total number of polymer chains	2
Total formula weight	123431.14
Authors	Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2016-10-24, release date: 2017-04-12, Last modification date: 2023-10-04)
Primary citation	Devine, W.G.,Diaz-Gonzalez, R.,Ceballos-Perez, G.,Rojas, D.,Satoh, T.,Tear, W.,Ranade, R.M.,Barros-Alvarez, X.,Hol, W.G.,Buckner, F.S.,Navarro, M.,Pollastri, M.P. From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis. ACS Infect Dis, 3:225-236, 2017 Cited by PubMed: 28110521 DOI: 10.1021/acsinfecdis.6b00202 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation