5TQU
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004825 | molecular_function | methionine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006431 | biological_process | methionyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004825 | molecular_function | methionine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006431 | biological_process | methionyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue MET A 800 |
| Chain | Residue |
| A | ILE248 |
| A | HOH938 |
| A | TYR249 |
| A | TYR250 |
| A | ASP287 |
| A | TRP474 |
| A | ALA477 |
| A | LEU478 |
| A | TYR481 |
| A | LYS550 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue I53 B 801 |
| Chain | Residue |
| B | ILE248 |
| B | TYR250 |
| B | ASP287 |
| B | HIS289 |
| B | GLY290 |
| B | VAL471 |
| B | VAL473 |
| B | TRP474 |
| B | ASP476 |
| B | TYR481 |
| B | PHE522 |
| B | SO4803 |
| B | HOH991 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 802 |
| Chain | Residue |
| B | ARG583 |
| B | ARG601 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| B | TYR250 |
| B | GLY290 |
| B | GLN291 |
| B | LYS292 |
| B | LEU456 |
| B | I53801 |
| B | HOH910 |
| B | HOH931 |
