5TQH

IDH1 R132H mutant in complex with IDH889

5TQH の概要

• エントリーDOI: 10.2210/pdb5tqh/pdb
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, CITRATE ANION, (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one, ... (5 entities in total)
• 機能のキーワード: isocitrate dehydrogenase, rossmann fold, nadph, inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : O75874
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 193133.58

構造登録者

Xie, X.,Kulathila, R. (登録日: 2016-10-24, 公開日: 2017-01-25, 最終更新日: 2024-03-06)

• 主引用文献: Levell, J.R.,Caferro, T.,Chenail, G.,Dix, I.,Dooley, J.,Firestone, B.,Fortin, P.D.,Giraldes, J.,Gould, T.,Growney, J.D.,Jones, M.D.,Kulathila, R.,Lin, F.,Liu, G.,Mueller, A.,van der Plas, S.,Slocum, K.,Smith, T.,Terranova, R.,Toure, B.B.,Tyagi, V.,Wagner, T.,Xie, X.,Xu, M.,Yang, F.S.,Zhou, L.X.,Pagliarini, R.,Cho, Y.S.; Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.; ACS Med Chem Lett, 8:151-156, 2017; PubMed: 28197303; DOI: 10.1021/acsmedchemlett.6b00334

実験手法

X-RAY DIFFRACTION (2.2 Å)