5TQ8

Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

5TQ8 の概要

• エントリーDOI: 10.2210/pdb5tq8/pdb
• 関連するPDBエントリー: 5TQ3 5TQ4 5TQ5 5TQ6 5TQ7 5TQ8
• 分子名称: Tyrosine-protein kinase JAK2, {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone (3 entities in total)
• 機能のキーワード: kinase, inflammation, jak inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : O60674
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35440.36

構造登録者

Chrencik, J.,Jones, P. (登録日: 2016-10-23, 公開日: 2017-01-11, 最終更新日: 2023-10-04)

• 主引用文献: Jones, P.,Storer, R.I.,Sabnis, Y.A.,Wakenhut, F.M.,Whitlock, G.A.,England, K.S.,Mukaiyama, T.,Dehnhardt, C.M.,Coe, J.W.,Kortum, S.W.,Chrencik, J.E.,Brown, D.G.,Jones, R.M.,Murphy, J.R.,Yeoh, T.,Morgan, P.,Kilty, I.; Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.; J. Med. Chem., 60:767-786, 2017; PubMed: 27983835; DOI: 10.1021/acs.jmedchem.6b01634

実験手法

X-RAY DIFFRACTION (1.59 Å)